Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AGER | Q15109 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9252619 | 0.90 | HDAC1 (0.51) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9261604 | 0.85 | HDAC1 (0.51) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9252884 | 0.84 | HDAC1 (0.46) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9251911 | 0.84 | HDAC1 (0.53) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL8925832 | 0.83 | PPARA (0.43) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9253807 | 0.83 | TSHR (0.54) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9253022 | 0.82 | PPARG (0.50) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9577853 | 0.82 | TSHR (0.56) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9259129 | 0.81 | HDAC1 (0.47) | TSHRHDAC1HDAC6HDAC3HDAC2 | |
| SCHEMBL9257832 | 0.80 | HDAC1 (0.44) | TSHRHDAC1HDAC6HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422373-A | An alkoxybenzyl-alkylene-arylurea anticholesterol, antilipemic agents and enzyme inhibitors | BURROUGHS WELLCOME CO. (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0550568-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992006075-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-04-16 | — | — | WO | disclosed |