SCHEMBL925783

SCHEMBL925783

COc1ccc(-c2oc3ccc(NC(C)=O)cc3c(=O)c2O)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 4/20 0.67
CSNK2B P67870 4/20 0.67
CSNK2A1 P68400 4/20 0.67
MAPT P10636 8/20 0.61
KDM4E B2RXH2 6/20 0.61
CYP3A4 P08684 5/20 0.61
TP53 P04637 5/20 0.61
MEN1 O00255 5/20 0.61
KMT2A Q03164 5/20 0.61
ALDH1A1 P00352 4/20 0.61
HSD17B10 Q99714 3/20 0.61
CASP1 P29466 2/20 0.61
CASP7 P55210 2/20 0.61
HPGD P15428 2/20 0.61
ACHE P22303 2/20 0.57
BACE1 P56817 2/20 0.57
ABCG2 Q9UNQ0 3/20 0.53
CYP1A1 P04798 1/20 0.52
CYP1A2 P05177 1/20 0.52
ABCB1 P08183 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17786540 0.91 CSNK2A2 (0.55) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL7639410 0.90 CSNK2A2 (0.66) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL17786576 0.89 ABCG2 (0.60) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL926285 0.88 MAPT (0.67) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
Hydrochloric Acid SCHEMBL926030 0.88 CSNK2A2 (0.64) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL17786357 0.88 MAPT (0.69) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL17786494 0.87 MAPT (0.69) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL12963109 0.86 MAPT (0.58) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL17786621 0.86 ACHE (0.55) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E
SCHEMBL5126244 0.86 KDM4E (0.64) CSNK2A2CSNK2BCSNK2A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2742033-B1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF ARMARON BIO PTY LTD (AU) 2018-09-19 EP claimed
US-20140275156-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2014-09-18 US claimed
EP-2742033-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF Neuprotect PTY Ltd (AU) 2014-06-18 EP claimed
WO-2013020184-A9 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2013-04-18 WO claimed
WO-2013020184-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2013-02-14 WO claimed
EP-2742033-B1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF ARMARON BIO PTY LTD (AU) 2018-09-19 EP disclosed
WO-2016083490-A1 COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES REMYND NV (BE) 2016-06-02 WO disclosed
US-20140275156-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2014-09-18 US disclosed
EP-2742033-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF Neuprotect PTY Ltd (AU) 2014-06-18 EP disclosed
WO-2013020184-A9 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2013-04-18 WO disclosed
WO-2013020184-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF NEUPROTECT PTY LTD (AU) 2013-02-14 WO disclosed
US-8372866-B2 2-aryl and 2-heteroaryl 4H-1-benzopyran-4-one-6-amidino derivatives, new pharmacological agents for the treatment of arthritis, cancer and related pain ROTTAPHARM S.P.A. (IT) 2013-02-12 US disclosed
EP-2268628-B1 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN ROTTAPHARM SPA (IT) 2012-05-16 EP disclosed
US-20110003861-A1 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN ROTTAPHARM S.P.A. (IT) 2011-01-06 US disclosed
EP-2268628-A1 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN Rottapharm S.p.A. (IT) 2011-01-05 EP disclosed
WO-2009109230-A1 2-ARYL AND 2 -HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN ROTTAPHARM S.P.A. (IT) 2009-09-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003861-A1 2-ARYL AND 2-HETEROARYL 4H-1-BENZOPYRAN-4-ONE-6-AMIDINO DERIVATIVES, NEW PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF ARTHRITIS, CANCER AND RELATED PAIN NAT1, AADAC, OPRL1 CSNK2A2 1153/4885CSNK2B 2039/4885CSNK2A1 1319/4885
US-20140275156-A1 FLAVONOID COMPOUNDS, AND METHODS OF USE THEREOF BAX, MAPKAPK2, MAPK6 CSNK2A2 2171/4885CSNK2B 1670/4885CSNK2A1 2244/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.