Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 17/20 | 0.63 |
| ▸ | TACR1 | P25103 | 2/20 | 0.63 |
| ▸ | TACR2 | P21452 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268872 | 0.85 | TACR2 (0.44) | HRH1TACR1TACR2ALDH1A1 | |
| SCHEMBL9264751 | 0.82 | HRH1 (0.72) | HRH1TACR1TACR2TP53CYP2D6 | |
| SCHEMBL9261674 | 0.82 | HRH1 (0.67) | HRH1TACR1TACR2TP53CYP2D6 | |
| SCHEMBL7958395 | 0.81 | HRH1 (0.64) | HRH1TACR1TACR2TP53ALDH1A1 | |
| SCHEMBL7468360 | 0.81 | HRH1 (0.63) | HRH1TACR1TACR2TP53CYP2D6 | |
| SCHEMBL9259609 | 0.81 | HRH1 (0.67) | HRH1TACR1TACR2TP53ALDH1A1 | |
| SCHEMBL9260703 | 0.80 | HRH1 (0.42) | HRH1TACR1TACR2TP53ALDH1A1 | |
| SCHEMBL9196229 | 0.80 | HRH1 (0.66) | HRH1TACR1TACR2TP53ALDH1A1 | |
| SCHEMBL9266568 | 0.79 | HRH1 (0.66) | HRH1TACR1TACR2TP53ALDH1A1 | |
| SCHEMBL9259200 | 0.79 | HRH1 (0.63) | HRH1TACR1TACR2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | claimed |
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |