Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 15/20 | 0.72 |
| ▸ | TACR1 | P25103 | 2/20 | 0.72 |
| ▸ | TACR2 | P21452 | 1/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259609 | 0.90 | HRH1 (0.67) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL9196229 | 0.88 | HRH1 (0.66) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL9697152 | 0.88 | HRH1 (0.73) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL9543189 | 0.87 | HRH1 (0.57) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL9259670 | 0.87 | HRH1 (0.69) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL9266568 | 0.86 | HRH1 (0.66) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL7474308 | 0.86 | HRH1 (0.62) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL9259200 | 0.86 | HRH1 (0.63) | HRH1TACR1TACR2CYP2D6KCNH2 | |
| SCHEMBL15568226 | 0.86 | HRH1 (0.63) | HRH1TACR1TACR2KCNH2 | |
| SCHEMBL9264591 | 0.85 | HRH1 (0.62) | HRH1TACR1TACR2CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |