Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.40 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.40 |
| ▸ | ECE1 | P42892 | 3/20 | 0.39 |
| ▸ | CPA1 | P15085 | 2/20 | 0.39 |
| ▸ | CPA3 | P15088 | 2/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.39 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9263230 | 0.90 | ACE2 (0.43) | ACE2MMEECE1 | |
| SCHEMBL9257787 | 0.87 | CYP1A2 (0.43) | ACE2CYP1A2FOLH1NAALAD2CPA1 | |
| SCHEMBL7491183 | 0.84 | CYP1A2 (0.47) | CYP1A2MMEFOLH1CPA1CPA3 | |
| SCHEMBL7490323 | 0.83 | CYP1A2 (0.46) | CYP1A2MMEFOLH1CPA1CPA3 | |
| SCHEMBL9258103 | 0.82 | MAPK1 (0.46) | CYP1A2FOLH1CPA1CPA3CPB1 | |
| SCHEMBL9254477 | 0.81 | CYP1A2 (0.43) | CYP1A2MMEFOLH1CPA1CPA3 | |
| SCHEMBL9259001 | 0.80 | CYP1A2 (0.47) | CYP1A2MMEFOLH1CPA1CPA3 | |
| SCHEMBL9263570 | 0.78 | CYP1A2 (0.40) | ACE2CYP1A2POLB | |
| SCHEMBL7493861 | 0.78 | CYP1A2 (0.54) | CYP1A2MMEFOLH1NAALAD2CPA1 | |
| SCHEMBL9259169 | 0.77 | MAPT (0.44) | CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393875-A | Hypotensive, cardiotonic and antiischemic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-02-28 | — | — | US | disclosed |