Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9131259 | 1.00 | ALDH1A1 (0.31) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9381813 | 0.98 | ALDH1A1 (0.32) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL9381806 | 0.98 | ALDH1A1 (0.32) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| Iodide SCHEMBL10508798 | 0.72 | ALDH1A1 (0.33) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7445082 | 0.69 | ALDH1A1 (0.33) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8548799 | 0.69 | SMN1; SMN2 (0.40) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8050690 | 0.68 | — | — | |
| SCHEMBL4095555 | 0.68 | — | — | |
| SCHEMBL11018010 | 0.63 | MEN1 (0.37) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| Iodide SCHEMBL1545549 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461050-A | Antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-10-24 | — | — | US | disclosed |
| EP-0588859-A1 | Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine derivatives, compositions and methods of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-03-30 | — | — | EP | disclosed |
| WO-1992022553-A1 | IMIDAZO[1,2-a](PYRROLO, THIENO OR FURANO)[3,2-d]AZEPINE DERIVATIVES, COMPOSITIONS AND METHODS OF USE | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-23 | — | — | WO | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| US-4634704-A | HISTAMINE AND SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-01-06 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |
| EP-0145037-A2 | N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |