Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 13/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 13/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 2/20 | 0.42 |
| ▸ | GABRD | O14764 | 2/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.42 |
| ▸ | GABRE | P78334 | 2/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9262960 | 0.85 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3569576 | 0.84 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3568502 | 0.84 | CA9 (0.37) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3569245 | 0.84 | KMT2A (0.53) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9266623 | 0.80 | GABRG2 (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3573042 | 0.78 | GABRG2 (0.53) | GABRG2GABRB3GABRA5CES1LRRK2 | |
| SCHEMBL3564162 | 0.77 | CNR1 (0.42) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8807582 | 0.74 | CNR1 (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2822931 | 0.74 | CNR1 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9261367 | 0.73 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387585-A | Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia | HOFFMANN-LA ROCHE INC. (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0519307-A2 | Tetracyclic Imidazodiazepines | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-23 | — | — | EP | disclosed |