Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ACR | P10323 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1090847 | 0.87 | THRB (0.59) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL346323 | 0.85 | THRB (0.48) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL20738260 | 0.84 | THRB (0.47) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL13962011 | 0.84 | THRB (0.47) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL12775995 | 0.84 | THRB (0.47) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL13732556 | 0.83 | THRB (0.46) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL25246107 | 0.82 | THRB (0.48) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL26527397 | 0.81 | THRB (0.45) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL21523649 | 0.81 | MEN1 (0.45) | THRBCYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL5823373 | 0.81 | MEN1 (0.45) | THRBCYP1A2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5439932-A | Anticholesterol agents | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-08 | — | — | US | disclosed |
| US-5306728-A | Substituted amine derivatives having antihyperlipemia activity | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-04-26 | — | — | US | disclosed |
| EP-0448078-A2 | Substituted amine derivatives having anti-hyperlipemia activity | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-09-25 | — | — | EP | disclosed |