Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.37 |
| ▸ | METAP2 | P50579 | 5/20 | 0.36 |
| ▸ | METAP1 | P53582 | 5/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 2/20 | 0.32 |
| ▸ | CTSH | P09668 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831980 | 0.81 | REN (0.37) | RENMETAP2METAP1 | |
| SCHEMBL10610858 | 0.81 | REN (0.37) | RENMETAP2METAP1 | |
| SCHEMBL5671311 | 0.79 | REN (0.40) | RENMETAP2METAP1CYP1A2 | |
| SCHEMBL5670653 | 0.77 | REN (0.38) | RENMETAP2METAP1 | |
| SCHEMBL9831663 | 0.77 | REN (0.38) | RENMETAP2METAP1CTSKCTSL | |
| SCHEMBL9832185 | 0.77 | REN (0.38) | RENMETAP2METAP1 | |
| SCHEMBL7436405 | 0.76 | REN (0.42) | RENMETAP2METAP1CYP1A2 | |
| SCHEMBL9833386 | 0.75 | REN (0.40) | RENMETAP2METAP1 | |
| SCHEMBL7321856 | 0.75 | REN (0.40) | RENMETAP2METAP1 | |
| SCHEMBL7435879 | 0.75 | REN (0.41) | RENMETAP2METAP1CTSKCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5389647-A | A prodrugs as hypotensive agents, treating congestive heart failure, urogenital disorders, vision defects | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |