⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200403 | 0.79 | — | — | |
| SCHEMBL16899660 | 0.74 | — | — | |
| SCHEMBL23892794 | 0.70 | — | — | |
| SCHEMBL16899631 | 0.70 | — | — | |
| SCHEMBL537197 | 0.67 | — | — | |
| SCHEMBL13974336 | 0.67 | DNM1 (0.33) | — | |
| SCHEMBL16899663 | 0.65 | — | — | |
| Hydrochloric Acid SCHEMBL4863550 | 0.64 | — | — | |
| Hydrochloric Acid SCHEMBL9339671 | 0.64 | — | — | |
| SCHEMBL31287505 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044122-B1 | ANTAGONIST ANTIBODY AGAINST EPHA2 FOR THE TREATMENT OF CANCER | SANOFI SA (FR) | 2018-03-28 | — | — | EP | claimed |
| US-20110002947-A1 | LEPTOMYCIN DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | US | claimed |
| US-7816543-B2 | Leptomycin derivatives | SANOFI-AVENTIS (FR) | 2010-10-19 | — | — | US | claimed |
| US-20090182038-A1 | Leptomycin Derivatives | SANOFI-AVENTIS (FR) | 2009-07-16 | — | — | US | claimed |
| US-20170343550-A1 | NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER | SANOFI SA (FR) | 2017-11-30 | — | — | US | disclosed |
| US-8952147-B2 | Conjugates, preparation thereof, and therapeutic use thereof | SANOFI (FR) | 2015-02-10 | — | — | US | disclosed |
| EP-2174644-B1 | Cosmetic composition comprising a dibenzoylmethane derivative and a dithiolane; Photostabilization of a dibenzoylmethane derivative | OREAL (FR) | 2012-11-14 | — | — | EP | disclosed |
| US-20120225089-A1 | NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-09-06 | — | — | US | disclosed |
| US-20110002947-A1 | LEPTOMYCIN DERIVATIVES | SANOFI-AVENTIS (FR) | 2011-01-06 | — | — | US | disclosed |
| US-7816543-B2 | Leptomycin derivatives | SANOFI-AVENTIS (FR) | 2010-10-19 | — | — | US | disclosed |
| US-20090182038-A1 | Leptomycin Derivatives | SANOFI-AVENTIS (FR) | 2009-07-16 | — | — | US | disclosed |