Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.61 |
| ▸ | PPARD | Q03181 | 1/20 | 0.61 |
| ▸ | PPARA | Q07869 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | AGER | Q15109 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | UBE2M | P61081 | 4/20 | 0.48 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260457 | 1.00 | PPARG (0.61) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9260923 | 0.99 | PPARG (0.59) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9261512 | 0.92 | PPARG (0.55) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9263100 | 0.92 | PPARG (0.55) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9260752 | 0.92 | PPARG (0.55) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9257865 | 0.92 | PPARG (0.55) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9265071 | 0.91 | PPARG (0.54) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9270364 | 0.88 | UBE2M (0.52) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9270367 | 0.88 | UBE2M (0.52) | PPARGPPARDPPARAPOLBNPC1 | |
| SCHEMBL9260551 | 0.86 | PPARG (0.67) | PPARGPPARDPPARAPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5384425-A | Diurea derivatives useful as medicaments and processes for the preparation thereof | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0325397-B1 | DIUREA DERIVATIVES USEFUL AS MEDICAMENTS AND PROCESSES FOR THE PREPARATION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5166429-A | Enzyme inhibitors of acylcoenzyme A cholesterol transferase as anticholesterol agents or antideposit agents | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5091419-A | Anticholesterol agent | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-25 | — | — | US | disclosed |