Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B known ✓ | P28222 | 3/20 | 0.64 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.64 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.64 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | HTR1E | P28566 | 1/20 | 0.64 |
| ▸ | HTR7 | P34969 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265318 | 0.95 | HTR1A (0.60) | HTR1AHTR1BDRD2DRD4HTR1E | |
| SCHEMBL7743816 | 0.95 | HTR1A (0.60) | HTR1AHTR1BDRD2DRD4HTR1E | |
| SCHEMBL2359786 | 0.95 | HTR1A (0.60) | HTR1AHTR1BDRD2DRD4HTR1E | |
| Oxalic Acid SCHEMBL9336277 | 0.94 | HTR1A (0.57) | HTR1AHTR1BDRD2DRD4HTR1E | |
| Hydrochloric Acid SCHEMBL9263041 | 0.94 | HTR1A (0.59) | HTR1AHTR1BDRD2DRD4HTR1E | |
| Succinic Acid SCHEMBL7109541 | 0.90 | HTR1B (0.78) | HTR1AHTR1BDRD2DRD4HTR1E | |
| Succinic Acid SCHEMBL7748928 | 0.90 | HTR1B (0.78) | HTR1AHTR1BDRD2DRD4HTR1E | |
| Succinic Acid SCHEMBL3801747 | 0.89 | HTR1B (0.80) | HTR1AHTR1BDRD2DRD4HTR1E | |
| SCHEMBL9336316 | 0.87 | HTR1A (0.58) | HTR1AHTR1BDRD2DRD4HTR1E | |
| Oxalic Acid SCHEMBL9334144 | 0.86 | HTR1A (0.56) | HTR1AHTR1BDRD2DRD4HTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674621-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014772-A1 | ENANTIOMERS OF CARBAZOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-07-07 | — | — | WO | disclosed |