Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4715461 | 0.83 | ADORA2A (0.62) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL2311045 | 0.83 | AXL (0.47) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL6859886 | 0.80 | PDE4A (0.50) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL9267742 | 0.78 | PDE4A (0.46) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL31462939 | 0.75 | ADORA2A (0.58) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL55563 | 0.75 | ADORA2A (0.58) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL1367259 | 0.72 | AXL (0.52) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL2876033 | 0.72 | AXL (0.52) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL5313545 | 0.72 | HTT (0.63) | AXLMKNK1MKNK2ADORA2AADORA1 | |
| SCHEMBL9263406 | 0.72 | HTR2C (0.45) | ADORA2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5387585-A | Treating epilepsy, anxiety, sleep disorders, schizophrnia, senile dementia | HOFFMANN-LA ROCHE INC. (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0519307-A2 | Tetracyclic Imidazodiazepines | F. HOFFMANN-LA ROCHE AG (CH) | 1992-12-23 | — | — | EP | disclosed |