Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9265400 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2RAB9ANPC1HSD11B1KMT2A | |
| SCHEMBL9268942 | 0.87 | NPC1 (0.35) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9268939 | 0.87 | NPC1 (0.35) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9268159 | 0.86 | FFAR1 (0.46) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9268156 | 0.86 | FFAR1 (0.46) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9266729 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9261268 | 0.85 | NPC1 (0.45) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9261261 | 0.85 | NPC1 (0.45) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9266726 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL9261705 | 0.85 | HPGD (0.46) | SMN1; SMN2RAB9AKMT2AALDH1A1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5476944-A | Inhibitors or stimulators of superoxide generation; may also inhibit cyclooxygenase and/or 5-lipoxygenase; useful in therapeutic or prophylactic treatment of disease conditions | G. D. SEARLE & CO. (US) | 1995-12-19 | — | — | US | disclosed |
| WO-1993010087-A1 | DERIVATIVES OF CYCLIC PHENOLIC THIOETHERS AS INHIBITORS OR STIMULATORS OF SUPEROXIDE GENERATION | G.D. SEARLE & CO. (US) | 1993-05-27 | — | — | WO | disclosed |