Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.67 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 1/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269677 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9266251 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9266247 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9269672 | 1.00 | OPRM1 (0.67) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9270129 | 0.88 | OPRM1 (0.51) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9678955 | 0.87 | OPRM1 (0.54) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9269099 | 0.87 | OPRM1 (0.64) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9272040 | 0.87 | OPRM1 (0.64) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9274287 | 0.87 | OPRM1 (0.64) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 | |
| SCHEMBL9269095 | 0.87 | OPRM1 (0.64) | OPRM1OPRD1OPRK1SIGMAR1SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214148-A | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides | GLAXO INC. (US) | 1993-05-25 | — | — | US | claimed |
| US-5387688-A | Intermediates for making analgesic N-phenyl-N-(3-OR1 -3-Me-4-piperidinyl)amides | GLAXO INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5214148-A | Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides | GLAXO INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5130321-A | Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides | GLAXO INC. (US) | 1992-07-14 | — | — | US | disclosed |