Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 4/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697745 | 1.00 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL17652166 | 0.78 | PDE4A (0.37) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL30775557 | 0.78 | MAP4K4 (0.40) | LMNASMN1; SMN2ALDH1A1EGFRKDM4E | |
| SCHEMBL15578362 | 0.74 | LRRK2 (0.30) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL9267455 | 0.73 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL31113992 | 0.73 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL18449614 | 0.73 | TNF (0.33) | — | |
| SCHEMBL28455625 | 0.71 | EGFR (0.37) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL28501805 | 0.70 | ALDH1A1 (0.37) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL31727757 | 0.70 | SMN1; SMN2 (0.34) | LMNASMN1; SMN2ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323356-A1 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | Nuvalent, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221227-A9 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | NUVALENT, INC. (US) | 2023-11-30 | — | — | WO | disclosed |
| WO-2022221227-A1 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | NUVALENT, INC. (US) | 2022-10-20 | — | — | WO | disclosed |