Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435444 | 0.95 | GAA (0.68) | GAANPSR1LMNAMAPTKDM4E | |
| SCHEMBL9267668 | 0.93 | GAA (0.70) | GAANPSR1MAPTKDM4EHPGD | |
| SCHEMBL12646476 | 0.88 | GAA (0.64) | GAANPSR1LMNAMAPTKDM4E | |
| SCHEMBL5386249 | 0.87 | MAPT (0.74) | GAANPSR1LMNAMAPTKDM4E | |
| SCHEMBL1853201 | 0.87 | GAA (0.62) | GAANPSR1MAPTKDM4EHPGD | |
| SCHEMBL4818057 | 0.84 | MAPT (0.57) | GAANPSR1LMNAMAPTKDM4E | |
| SCHEMBL11815554 | 0.84 | GAA (0.72) | GAANPSR1MAPTKDM4EHPGD | |
| SCHEMBL4816077 | 0.84 | GAA (0.59) | GAANPSR1LMNAMAPTKDM4E | |
| SCHEMBL12646489 | 0.84 | GAA (0.59) | GAANPSR1MAPTKDM4EHPGD | |
| SCHEMBL12629414 | 0.83 | GAA (0.57) | GAANPSR1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995029155-A1 | NOVEL ANTITUMOUR COMPOUNDS WITH ANTIMITOTIC ACTIVITY | PHARMACIA AB (SE) | 1995-11-02 | — | — | WO | disclosed |