Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL434786 | 0.95 | GAA (0.68) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL9267668 | 0.93 | GAA (0.70) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL12646476 | 0.88 | GAA (0.64) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL1550341 | 0.87 | GAA (0.59) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL9268449 | 0.87 | GAA (0.62) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL5386249 | 0.87 | MAPT (0.74) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL12646482 | 0.85 | KDM4E (0.57) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL29226837 | 0.84 | GAA (0.56) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL11815554 | 0.84 | GAA (0.72) | GAANPSR1KDM4EHPGDHSD17B10 | |
| SCHEMBL4816077 | 0.84 | GAA (0.59) | GAANPSR1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105608-A1 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING | NORTHEASTERN UNIVERSITY (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105608-A1 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING | NORTHEASTERN UNIVERSITY (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105608-A1 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING | NORTHEASTERN UNIVERSITY (US) | 2011-05-05 | — | — | US | disclosed |
| WO-2009117739-A1 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING | NORTHEASTERN UNIVERSITY (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-1995029155-A1 | NOVEL ANTITUMOUR COMPOUNDS WITH ANTIMITOTIC ACTIVITY | PHARMACIA AB (SE) | 1995-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105608-A1 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING | ESRRB, ESRRA, ESRRG | GAA 4645/4885NPSR1 1494/4885KDM4E 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.