Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | FAAH | O00519 | 4/20 | 0.65 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | CRHBP | P24387 | 1/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21295428 | 0.96 | SMN1; SMN2 (0.74) | ALDH1A1SMN1; SMN2GAAHTTHPGD | |
| Phenyl Phenylcarbamate SCHEMBL272994 | 0.92 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2GAAHTTMAPT | |
| SCHEMBL8060143 | 0.89 | MAPT (0.69) | ALDH1A1SMN1; SMN2GAAHTTHPGD | |
| SCHEMBL21234443 | 0.89 | HPGD (0.69) | ALDH1A1SMN1; SMN2GAAHTTHPGD | |
| SCHEMBL5406539 | 0.89 | SMN1; SMN2 (0.64) | ALDH1A1SMN1; SMN2GAAHTTHPGD | |
| SCHEMBL8063648 | 0.88 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2GAAHTTHPGD | |
| SCHEMBL13104404 | 0.88 | CA12 (0.61) | ALDH1A1SMN1; SMN2GAAHTTHPGD | |
| Phenyl Phenylcarbamate SCHEMBL27565311 | 0.87 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2GAAHTTMAPT | |
| SCHEMBL9480270 | 0.85 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2GAAHTTMAPT | |
| SCHEMBL9480551 | 0.85 | ALDH1A1 (0.72) | ALDH1A1SMN1; SMN2GAAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5391571-A | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-02-21 | — | — | US | claimed |
| US-5391571-A | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0428385-A1 | Cholesterol ester hydrolase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-22 | — | — | EP | disclosed |