Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30433473 | 0.90 | POLB (0.66) | POLBARALDH1A1HPGDKDM4E | |
| SCHEMBL9266124 | 0.79 | PDE3B (0.49) | POLBARALDH1A1HPGDKDM4E | |
| SCHEMBL9269627 | 0.76 | HTT (0.51) | POLBARALDH1A1HPGDKDM4E | |
| SCHEMBL3023400 | 0.75 | HPGD (0.63) | POLBALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL9270801 | 0.74 | MAPT (0.55) | ARALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL7051937 | 0.74 | HPGD (0.53) | POLBARALDH1A1HPGDMAPT | |
| SCHEMBL4717450 | 0.73 | POLB (0.50) | POLBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7051466 | 0.72 | HPGD (0.50) | POLBARALDH1A1HPGDMAPT | |
| SCHEMBL26601966 | 0.71 | LMNA (0.56) | POLBALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7017757 | 0.71 | KDM4E (0.60) | POLBALDH1A1KDM4EMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420275-A | Chemiluminescent assay, tumors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-05-30 | — | — | US | disclosed |
| EP-0491477-A1 | Pyridopyridazine compounds and their use | Takeda Chemical Industries, Ltd. (JP) | 1992-06-24 | — | — | EP | disclosed |