Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.42 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30463761 | 0.88 | ABCG2 (0.44) | MAPTALDH1A1TP53NOTUMTAS2R14 | |
| SCHEMBL22556444 | 0.88 | ABCG2 (0.44) | MAPTALDH1A1TP53NOTUMTAS2R14 | |
| SCHEMBL9263048 | 0.81 | MAPT (0.58) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL9261281 | 0.80 | MAPT (0.51) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL3491241 | 0.78 | AURKA (0.48) | MAPTGAATHRBNOTUM | |
| SCHEMBL9260582 | 0.77 | KDR (0.49) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL7830009 | 0.76 | NOTUM (0.61) | MAPTGAARAB9ASMN1; SMN2THRB | |
| Hydrochloric Acid SCHEMBL9265237 | 0.74 | MAPT (0.47) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9265224 | 0.74 | KDR (0.46) | MAPTALDH1A1GAARAB9ASMN1; SMN2 | |
| SCHEMBL27857659 | 0.73 | NOTUM (0.56) | ALDH1A1RAB9ASMN1; SMN2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5462952-A | Have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase | WARNER-LAMBERT COMPANY (US) | 1995-10-31 | — | — | US | claimed |
| EP-0401857-A2 | Fenamate 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1990-12-12 | — | — | EP | claimed |
| US-5462952-A | Have activity as inhibitors of 5-lipoxygenase and/or cyclooxygenase | WARNER-LAMBERT COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0401857-A2 | Fenamate 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as antiinflammatory agents | WARNER-LAMBERT COMPANY (US) | 1990-12-12 | — | — | EP | disclosed |