⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2666532 | 0.72 | — | — | |
| SCHEMBL219636 | 0.72 | — | — | |
| SCHEMBL14119004 | 0.71 | — | — | |
| SCHEMBL28236342 | 0.69 | NOS1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL11773177 | 0.69 | — | — | |
| Bromide SCHEMBL11604984 | 0.69 | — | — | |
| Hydrochloric Acid SCHEMBL4901904 | 0.69 | — | — | |
| Bromide SCHEMBL11604987 | 0.69 | — | — | |
| SCHEMBL11802236 | 0.69 | NOS1 (0.43) | — | |
| SCHEMBL28100459 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341103-A | Aminoguanidinohydrazones as reverse transporter stabilizers useful for the treatment of neurological disorders | 圣拉斐尔医院有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-114341103-A | Aminoguanidinohydrazones as reverse transporter stabilizers useful for the treatment of neurological disorders | 圣拉斐尔医院有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-114341103-A | Aminoguanidinohydrazones as reverse transporter stabilizers useful for the treatment of neurological disorders | 圣拉斐尔医院有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-114341103-A | Aminoguanidinohydrazones as reverse transporter stabilizers useful for the treatment of neurological disorders | 圣拉斐尔医院有限公司 | 2022-04-12 | — | — | CN | disclosed |
| EP-1849774-B1 | CYCLOHEPTA(b)PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | TOA EIYO LTD (JP) | 2011-06-29 | — | — | EP | disclosed |
| US-7875625-B2 | 3-guanidinocarbonyl-2-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ylmethyl hydrogen sulfate, inhibitory effect on an Na+/H+ exchanger; | TOA EIYO LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| CN-101119971-B | Cyclohepta[b]pyridine-3-carbonylguanidine derivative and pharmaceutical product containing same | TOA EIYO LTD | 2010-09-08 | — | — | CN | disclosed |
| US-20090012114-A1 | Cyclohepta[B]Pyridine-3-Carbonylguanidine Derivative and Pharmaceutical Product Containing Same | TOA EIYO LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| CN-101119971-A | Cyclohepta[b]pyridine-3-carbonylguanidine derivative and pharmaceutical product containing same | TOA EIYO LTD (JP) | 2008-02-06 | — | — | CN | disclosed |
| EP-1849774-A1 | CYCLOHEPTA(b)PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | TOA EIYO LTD. (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |