Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9269544 | 1.00 | ALB (0.35) | ALBALDH1A1SMN1; SMN2CASP1NOS3 | |
| SCHEMBL9261501 | 0.85 | ALB (0.35) | ALBALDH1A1KDM4EPOLBCYP3A4 | |
| SCHEMBL9261513 | 0.85 | ALB (0.35) | ALBALDH1A1KDM4EPOLBCYP3A4 | |
| SCHEMBL9256170 | 0.79 | ALDH1A1 (0.40) | ALBALDH1A1SMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL9256181 | 0.79 | ALDH1A1 (0.40) | ALBALDH1A1SMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL9260315 | 0.77 | ALB (0.49) | ALBTSHR | |
| SCHEMBL5777449 | 0.77 | ALB (0.49) | ALBTSHR | |
| SCHEMBL27572318 | 0.71 | ALB (0.39) | ALB | |
| SCHEMBL5779199 | 0.71 | ALB (0.39) | ALB | |
| SCHEMBL5775269 | 0.70 | ALB (0.42) | ALBNOS3NOS1NOS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5399702-A | Leukotriene antagonists; antiasthmatic, antiallergen, and antianaphylactic agents | HOFFMANN-LA ROCHE INC. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0577003-A1 | Thiazolylvinylphenyl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-05 | — | — | EP | disclosed |
| US-5273986-A | A substituted phenylalkyleneamidophenyleneethylene thiazole | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |