Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 3/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957482 | 0.93 | HMGCR (0.58) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL7558276 | 0.88 | HMGCR (0.77) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9271666 | 0.85 | HMGCR (0.59) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9271680 | 0.85 | HMGCR (0.59) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9270541 | 0.84 | HMGCR (0.62) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9270549 | 0.84 | HMGCR (0.62) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL29623831 | 0.82 | HMGCR (0.69) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9743399 | 0.81 | HMGCR (0.64) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9743387 | 0.81 | HMGCR (0.64) | HMGCRESR1CHRM1TBXA2RPDE4A | |
| SCHEMBL9152557 | 0.81 | HMGCR (0.66) | HMGCRESR1CHRM1TBXA2RPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401746-A | FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND HMG-COA REDUCTASE | BAYER AKTIENGESELLSCHAFT (DE) | 1995-03-28 | — | — | US | disclosed |
| US-5169857-A | Anticholesterol agents | BAYER AKTIENGESELLSCHAFT (DE) | 1992-12-08 | — | — | US | disclosed |
| US-5006530-A | Certain 7-[2,6-diisopropyl-4-phenyl-5-lower alkoxymethyl-pyrid-3-yl]-3,5-dihydroxy-6-enoates and derivatives useful for treating circulatory diseases | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-09 | — | — | US | disclosed |