Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 8/20 | 0.87 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.49 |
| ▸ | MTOR | P42345 | 4/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629606 | 0.93 | PIK3CB (1.00) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6625427 | 0.93 | PIK3CB (1.00) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL3594472 | 0.88 | PIK3CB (0.90) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6626404 | 0.87 | PIK3CB (0.87) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL20078072 | 0.87 | PIK3CB (0.87) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6623601 | 0.86 | PIK3CB (0.81) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6627240 | 0.86 | PIK3CB (0.85) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6626263 | 0.86 | PIK3CB (0.85) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL6625463 | 0.86 | PIK3CB (0.85) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL6625296 | 0.85 | PIK3CB (0.83) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276750-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | Auckland Uniservices Limited (NZ) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009120094-A2 | SUBSTITUTED PYRIMIDINES AND TRIAZINES AND THEIR USE IN CANCER THERAPY | AUCKLAND UNISERVICES LIMITED (NZ) | 2009-10-01 | — | — | WO | disclosed |