Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 9/20 | 0.85 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629606 | 0.92 | PIK3CB (1.00) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL6625427 | 0.92 | PIK3CB (1.00) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL6625425 | 0.89 | PIK3CB (0.67) | PIK3CBPIK3CDHRH4LCKMKNK1 | |
| SCHEMBL20078072 | 0.89 | PIK3CB (0.87) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL3594472 | 0.87 | PIK3CB (0.90) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL927196 | 0.86 | PIK3CB (0.87) | PIK3CBPIK3CDPIK3CAPIK3CGHRH4 | |
| SCHEMBL6626404 | 0.86 | PIK3CB (0.87) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL931986 | 0.85 | PIK3CB (0.81) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL6623601 | 0.85 | PIK3CB (0.81) | PIK3CBPIK3CDPIK3CAPIK3CGLCK | |
| SCHEMBL6626263 | 0.85 | PIK3CB (0.85) | PIK3CBPIK3CDPIK3CAPIK3CGLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040912-A1 | PIPERAZINOTRIAZINES AS PI3K INHIBITORS FOR USE IN THE TREATMENT ANTIPROLIFERATIVE DISORDERS | UNIVERSITY OF BASEL (CH) | 2013-02-14 | — | — | US | disclosed |
| US-20130040912-A1 | PIPERAZINOTRIAZINES AS PI3K INHIBITORS FOR USE IN THE TREATMENT ANTIPROLIFERATIVE DISORDERS | UNIVERSITY OF BASEL (CH) | 2013-02-14 | — | — | US | disclosed |
| WO-2011135520-A1 | PIPERAZINOTRIAZINES AS PI3K INHIBITORS FOR USE IN THE TREATMENT ANTIPROLIFERATIVE DISORDERS | UNIVERSITY OF BASEL (CH) | 2011-11-03 | — | — | WO | disclosed |
| EP-1020462-B1 | HETEROCYCLIC COMPOUNDS AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT | ZENYAKU KOGYO KK (JP) | 2004-02-11 | — | — | EP | disclosed |
| US-6251900-B1 | Heterocyclic compounds and antitumor agent containing the same as active ingredient | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2001-06-26 | — | — | US | disclosed |
| CN-1271355-A | Heterocyclic compounds and antitumor agent containing the same as active ingredient | ZENYADKU KOGYO K K (JP) | 2000-10-25 | — | — | CN | disclosed |
| EP-1020462-A1 | HETEROCYCLIC COMPOUNDS AND ANTITUMOR AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 2000-07-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040912-A1 | PIPERAZINOTRIAZINES AS PI3K INHIBITORS FOR USE IN THE TREATMENT ANTIPROLIFERATIVE DISORDERS | CDK4, MTOR, RPTOR | PIK3CB 41/4885PIK3CD 25/4885PIK3CA 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.