Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.49 |
| ▸ | RARB | P10826 | 6/20 | 0.49 |
| ▸ | RARG | P13631 | 6/20 | 0.49 |
| ▸ | RARA | P10276 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.45 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | RXRB | P28702 | 3/20 | 0.36 |
| ▸ | RXRG | P48443 | 3/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | ACACB | O00763 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9268679 | 0.93 | RARB (0.47) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9263088 | 0.86 | CYP3A4 (0.54) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9271587 | 0.85 | RARB (0.48) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9271965 | 0.85 | CYP3A4 (0.49) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL19342943 | 0.83 | CYP3A4 (0.58) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9257896 | 0.82 | CYP26A1 (0.46) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9264954 | 0.82 | RARB (0.51) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9673775 | 0.81 | RARA (0.65) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL6684655 | 0.81 | RARA (0.46) | CYP3A4RARBRARGRARAKMT2A | |
| SCHEMBL9267411 | 0.80 | CYP26A1 (0.54) | CYP3A4RARBRARGRARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5466690-A | Treating psoriasis | ALLERGAN, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5354776-A | Treating psoriasis | ALLERGAN, INC. (US) | 1994-10-11 | — | — | US | disclosed |
| EP-0284261-B1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN INC (US) | 1994-01-05 | — | — | EP | disclosed |
| US-5246962-A | Psoriasis, skin disorders | ALLERGAN, INC. (US) | 1993-09-21 | — | — | US | disclosed |
| US-5149705-A | Treatment of psoriasis | ALLERGAN, INC. (US) | 1992-09-22 | — | — | US | disclosed |
| EP-0284261-A1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN, INC (US) | 1988-09-28 | — | — | EP | disclosed |