Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9104486 | 0.89 | HRH3 (0.44) | HRH3HDAC8OPRK1CYP2D6OPRM1 | |
| SCHEMBL9104502 | 0.89 | HRH3 (0.44) | HRH3HDAC8OPRK1CYP2D6OPRM1 | |
| SCHEMBL9275957 | 0.87 | HRH3 (0.44) | HRH3OPRK1CYP2D6OPRM1OPRD1 | |
| SCHEMBL9277511 | 0.86 | HDAC8 (0.45) | HDAC8CYP2D6TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9280528 | 0.86 | HDAC8 (0.47) | HRH3HDAC8OPRK1TAS1R3TAS1R1 | |
| SCHEMBL9280428 | 0.83 | SMO (0.41) | OPRK1CYP2D6OPRM1OPRD1CCR5 | |
| SCHEMBL9279362 | 0.82 | HDAC8 (0.42) | HDAC8OPRK1CYP2D6OPRD1TAS1R3 | |
| SCHEMBL9279426 | 0.81 | HRH3 (0.39) | HRH3OPRK1OPRM1OPRD1 | |
| SCHEMBL9105408 | 0.79 | HDAC8 (0.42) | HRH3HDAC8OPRK1CYP2D6TAS1R3 | |
| SCHEMBL9105399 | 0.79 | HDAC8 (0.42) | HRH3HDAC8OPRK1CYP2D6TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |