Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | UBE2M | P61081 | 5/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 5/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9105399 | 1.00 | HDAC8 (0.42) | HDAC8UBE2MDCUN1D1TAS1R3TAS1R1 | |
| SCHEMBL9105962 | 0.88 | OPRK1 (0.37) | TAS1R3TAS1R1TAS1R2OPRK1CCR5 | |
| SCHEMBL9104979 | 0.88 | OPRK1 (0.37) | TAS1R3TAS1R1TAS1R2OPRK1CCR5 | |
| SCHEMBL31478912 | 0.88 | OPRK1 (0.37) | TAS1R3TAS1R1TAS1R2OPRK1CCR5 | |
| SCHEMBL9102296 | 0.86 | OPRK1 (0.36) | OPRK1HRH3 | |
| SCHEMBL9102284 | 0.86 | OPRK1 (0.36) | OPRK1HRH3 | |
| SCHEMBL9100354 | 0.85 | OPRK1 (0.43) | UBE2MDCUN1D1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL31478849 | 0.85 | OPRK1 (0.43) | UBE2MDCUN1D1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9100342 | 0.85 | OPRK1 (0.43) | UBE2MDCUN1D1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9102141 | 0.85 | CCR5 (0.43) | CYP2D6OPRK1CCR5HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130143858-A1 | COMPOUNDS AND THEIR USE AS IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2013-06-06 | — | — | US | disclosed |
| US-8361998-B2 | Compounds and their use as IKACh blockers | ASTRAZENECA AB | 2013-01-29 | — | — | US | disclosed |
| US-20120142659-A1 | COMPOUNDS AND THEIR USE AS IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143858-A1 | COMPOUNDS AND THEIR USE AS IKACH BLOCKERS | KCNH2, KCNJ2, KCNH3 | HDAC8 1995/4885UBE2M 2018/4885DCUN1D1 2889/4885 |
| US-20120142659-A1 | COMPOUNDS AND THEIR USE AS IKACH BLOCKERS | KCNH2, KCNJ2, KCNH3 | HDAC8 1995/4885UBE2M 2018/4885DCUN1D1 2889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.