Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557662 | 0.89 | ALOX5 (0.47) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9275052 | 0.88 | ALOX5 (0.58) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9280770 | 0.87 | ALOX5 (0.58) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9280765 | 0.87 | ALOX5 (0.58) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9280772 | 0.87 | ALOX5 (0.58) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9100476 | 0.87 | ALOX5 (0.58) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9271466 | 0.80 | ALOX5 (0.45) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL9275295 | 0.80 | ALOX5 (0.45) | ALOX5PDE3BPDE3ATRIM24CYP11B2 | |
| SCHEMBL2108616 | 0.79 | ALOX5 (0.46) | ALOX5TRIM24CYP11B2METAP2GABRG2 | |
| SCHEMBL2107548 | 0.78 | ALOX5 (0.43) | ALOX5PDE3BPDE3ATRIM24CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995030668-A1 | CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ZENECA LIMITED (GB) | 1995-11-16 | — | — | WO | claimed |
| WO-1995030668-A1 | CYCLIC ETHER DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | ZENECA LIMITED (GB) | 1995-11-16 | — | — | WO | disclosed |