Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836356 | 0.76 | FOLH1 (0.44) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL10930315 | 0.76 | NPC1 (0.44) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL10580678 | 0.74 | FOLH1 (0.49) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL23957738 | 0.72 | RECQL (0.45) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL8445805 | 0.72 | FOLH1 (0.45) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL8447511 | 0.72 | FOLH1 (0.45) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL14938949 | 0.72 | FOLH1 (0.45) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL18573967 | 0.71 | LMNA (0.44) | NPC1RAB9AKMT2AALDH1A1TDP1 | |
| SCHEMBL31651007 | 0.71 | NPC1 (0.49) | MAPTNPC1RAB9APOLBGAA | |
| SCHEMBL31651021 | 0.71 | NPC1 (0.49) | MAPTNPC1RAB9APOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656790-A1 | COMPOSITIONS AND METHODS FOR MODULATING RNA | ISIS PHARMACEUTICALS, INC. (US) | 1995-06-14 | — | — | EP | disclosed |
| WO-1993017717-A1 | COMPOSITIONS AND METHODS FOR MODULATING RNA | ISIS PHARMACEUTICALS, INC. (US) | 1993-09-16 | — | — | WO | disclosed |