Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC16A3 | O15427 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562418 | 1.00 | SLC16A3 (0.58) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| Water SCHEMBL9265852 | 0.98 | SLC16A3 (0.56) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL928140 | 0.89 | PTGER4 (0.50) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL929442 | 0.88 | PTGER4 (0.51) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL927912 | 0.88 | SLC16A3 (0.50) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL3426837 | 0.87 | SLC16A3 (0.55) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL927918 | 0.85 | CNR1 (0.64) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL29562238 | 0.85 | CNR1 (0.56) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL928072 | 0.85 | CNR1 (0.56) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E | |
| SCHEMBL929057 | 0.84 | TDP1 (0.48) | SLC16A3PDE5ACYP1A2CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 185 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106518769-A | Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates | 方济各安吉利克化学联合股份有限公司 | 2017-03-22 | — | — | CN | claimed |
| CN-102471281-B | Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2014-10-15 | — | — | CN | claimed |
| EP-2462119-B1 | Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates | ACRAF (IT) | 2014-06-11 | — | — | EP | claimed |
| EP-2462118-B1 | Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required Magnesium intermediates | ACRAF (IT) | 2014-06-11 | — | — | EP | claimed |
| US-8354544-B2 | Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required magnesium intermediates | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2013-01-15 | — | — | US | claimed |
| US-8350052-B2 | Process for the preparation of 1-benzyl-3-hydroxymethyl-1H-indazole and its derivatives and required magnesium intermediates | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2013-01-08 | — | — | US | claimed |
| US-20120220636-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED INFLAMMATORY DISEASES | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F.S.P.A. (IT) | 2012-08-30 | — | — | US | claimed |
| EP-2480224-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED INFLAMMATORY DISEASES | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) | 2012-08-01 | — | — | EP | claimed |
| US-20120184752-A1 | PROCESS FOR THE PREPARATION OF 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE AND ITS DERIVATIVES AND REQUIRED MAGNESIUM INTERMEDIATES | AZIENDE CHIM, RIUN, ANG, FRANC. A.C.R.A.F. S.p.A. (IT) | 2012-07-19 | — | — | US | claimed |
| CN-102573827-A | Pharmaceutical composition for the treatment of MCP-1 mediated inflammatory diseases | ACRAF | 2012-07-11 | — | — | CN | claimed |
| US-20120149912-A1 | PROCESS FOR THE PREPARATION OF 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE AND ITS DERIVATIVES AND REQUIRED MAGNESIUM INTERMEDIATES | AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.P.A. (IT) | 2012-06-14 | — | — | US | claimed |
| CN-102471282-A | 1-benzyl-3-hydroxymethyl-1H-indazole and derivatives thereof and process for the preparation of the desired magnesium intermediate | ACRAF | 2012-05-23 | — | — | CN | claimed |
| CN-102471281-A | 1-benzyl-3-hydroxymethyl-1H-indazole and derivatives thereof and process for the preparation of the desired magnesium intermediate | ACRAF | 2012-05-23 | — | — | CN | claimed |
| WO-2011036047-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED INFLAMMATORY DISEASES | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2011-03-31 | — | — | WO | claimed |
| CN-1842332-A | Compounds, compositions and methods | HIF BIO INC (US) | 2006-10-04 | — | — | CN | claimed |
| JP-2240065-A | — | — | None | — | — | JP | disclosed |
| EP-3990433-B1 | PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES | TRANSLATUM MEDICUS INC (CA) | 2026-05-20 | — | — | EP | disclosed |
| CN-1044810-A | Ethers of 1-benzyl-3-hydroxymethyl-indazole and aliphatic-2-hydroxy acids | ACRAF (IT) | 1990-08-22 | — | — | CN | disclosed |
| EP-0382276-A2 | Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 1990-08-16 | — | — | EP | disclosed |
| EP-0382276-A2 | Ethers of 1-benzyl-3-hydroxymethyl-indazole with aliphatic 2-hydroxyacids | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 1990-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220636-A1 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF MCP-1 MEDIATED INFLAMMATORY DISEASES | ACE, ACE2, CCL11 | SLC16A3 2310/4885PDE5A 687/4885CYP1A2 798/4885 |
| US-20120184752-A1 | PROCESS FOR THE PREPARATION OF 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE AND ITS DERIVATIVES AND REQUIRED MAGNESIUM INTERMEDIATES | CYP2E1, CYP3A4, CYP1A1 | SLC16A3 3101/4885PDE5A 4261/4885CYP1A2 13/4885 |
| US-20120149912-A1 | PROCESS FOR THE PREPARATION OF 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE AND ITS DERIVATIVES AND REQUIRED MAGNESIUM INTERMEDIATES | CYP2E1, CYP3A4, CYP1B1 | SLC16A3 2646/4885PDE5A 4209/4885CYP1A2 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.