Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920594 | 0.79 | GAA (0.42) | JAK2JAK1JAK3KMT2AGAA | |
| SCHEMBL9106683 | 0.77 | APP (0.36) | KMT2ALMNAMEN1APPBCHE | |
| SCHEMBL29459700 | 0.69 | CDK4 (0.54) | JAK2JAK1JAK3HTTCDK4 | |
| SCHEMBL24900120 | 0.67 | S1PR2 (0.45) | KMT2AMEN1MAPT | |
| SCHEMBL9103257 | 0.67 | APP (0.35) | KMT2AGAAALDH1A1KDM4EHTT | |
| SCHEMBL9104296 | 0.67 | BCDIN3D (0.42) | JAK2JAK1JAK3KMT2AGAA | |
| SCHEMBL9235181 | 0.67 | BCDIN3D (0.37) | KMT2AGAAHTTLMNAMEN1 | |
| SCHEMBL25979373 | 0.66 | MAPK1 (0.45) | KMT2AALDH1A1KDM4EHTTLMNA | |
| SCHEMBL26656303 | 0.66 | APP (0.34) | KMT2AGAAALDH1A1KDM4EHTT | |
| SCHEMBL9235868 | 0.65 | CYP1A2 (0.35) | KMT2ALMNAMEN1APPBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646423-A1 | NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES | Galleon Pharmaceuticals, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012074999-A1 | NOVEL COMPOUNDS AS RESPIRATORY STIMULANTS FOR TREATMENT OF BREATHING CONTROL DISORDERS OR DISEASES | GALLEON PHARMACEUTICALS, INC. (US) | 2012-06-07 | — | — | WO | disclosed |