Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 5/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920250 | 0.91 | PTPN1 (0.44) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9913930 | 0.90 | PTPN1 (0.44) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9103709 | 0.89 | S1PR1 (0.55) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9103441 | 0.86 | S1PR1 (0.57) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9103408 | 0.85 | PTPN1 (0.48) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9101175 | 0.81 | PTPN1 (0.45) | PTPN1S1PR1S1PR3MAPTTP53 | |
| SCHEMBL27920426 | 0.81 | PTPN1 (0.44) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL28807635 | 0.80 | PTPN1 (0.48) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL9912337 | 0.79 | PTPN1 (0.44) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL15675888 | 0.79 | PTPN1 (0.42) | PTPN1S1PR1S1PR3S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2646021-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P)RECEPTOR MODULATORS | Allergan, Inc. (US) | 2013-10-09 | — | — | EP | claimed |
| WO-2012074730-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P)RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-07 | — | — | WO | claimed |
| EP-2646021-B1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P)RECEPTOR MODULATORS | ALLERGAN INC (US) | 2014-11-05 | — | — | EP | disclosed |
| EP-2646021-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P)RECEPTOR MODULATORS | Allergan, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012074730-A1 | OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P)RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2012-06-07 | — | — | WO | disclosed |