Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 8/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666559 | 0.73 | HTR4 (0.49) | HTR4ADRA2CHTR1DADRA1BHTR2B | |
| SCHEMBL14905735 | 0.73 | HTR4 (0.72) | HTR4ADRA2CHTR1DADRA1BHTR2B | |
| SCHEMBL9341467 | 0.71 | HTR4 (0.71) | HTR4CYP1A2CYP2C9 | |
| SCHEMBL13036127 | 0.70 | HTR4 (0.80) | HTR4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9342314 | 0.69 | HTR4 (0.58) | HTR4CYP1A2CYP2C9 | |
| SCHEMBL13439990 | 0.69 | HTR4 (0.76) | HTR4ADRA2CHTR1DADRA1BHTR2B | |
| SCHEMBL7325724 | 0.69 | CHRM1 (0.41) | HTR4ADRA1BADRA2BADRA1ACHRM4 | |
| SCHEMBL7323178 | 0.68 | HTR4 (0.72) | HTR4ADRA2CHTR1DADRA1BHTR2B | |
| SCHEMBL7391969 | 0.67 | HTR4 (0.78) | HTR4ADRA2CHTR1DADRA1BHTR2B | |
| SCHEMBL7393472 | 0.67 | HTR4 (0.58) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664805-A1 | HETEROCYCLIC -ESTERS OR -AMIDES USED AS 5-HT 4? RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-08-02 | — | — | EP | claimed |