Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 2/20 | 0.40 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260991 | 0.86 | HRH1 (0.51) | HRH1TACR2TACR1LMNAPOLB | |
| SCHEMBL9282529 | 0.83 | HRH1 (0.40) | HRH1TACR2TACR1LMNAREN | |
| SCHEMBL9282339 | 0.83 | HRH1 (0.39) | HRH1TACR2TACR1LMNAPOLB | |
| SCHEMBL9268456 | 0.82 | TACR2 (0.53) | HRH1TACR2TACR1LMNAPOLB | |
| SCHEMBL9282864 | 0.82 | HRH1 (0.47) | HRH1TACR2TACR1KCNH2ALDH1A1 | |
| SCHEMBL9284043 | 0.79 | HRH1 (0.51) | HRH1TACR2TACR1KCNH2 | |
| SCHEMBL9259123 | 0.77 | TACR2 (0.45) | HRH1TACR2TACR1LMNAPOLB | |
| SCHEMBL9264749 | 0.72 | HRH1 (0.41) | HRH1TACR2TACR1KCNH2MAPK1 | |
| SCHEMBL9260984 | 0.71 | HRH1 (0.70) | HRH1TACR2TACR1LMNAPOLB | |
| SCHEMBL9259114 | 0.70 | HRH1 (0.73) | HRH1TACR2TACR1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |