Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 1/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260991 | 0.85 | HRH1 (0.51) | TACR2TACR1HRH1LMNAOPRM1 | |
| SCHEMBL9259123 | 0.83 | TACR2 (0.45) | TACR2TACR1HRH1LMNAMAPT | |
| SCHEMBL9282500 | 0.82 | HRH1 (0.48) | TACR2TACR1HRH1LMNAMAPT | |
| SCHEMBL9268450 | 0.82 | TACR2 (0.77) | TACR2TACR1HRH1PTGDR2LMNA | |
| SCHEMBL9268866 | 0.80 | HRH1 (0.43) | TACR2TACR1HRH1PTGDR2MAPT | |
| SCHEMBL9260978 | 0.78 | KDM4E (0.50) | TACR2TACR1HRH1PTGDR2ALDH1A1 | |
| SCHEMBL9268872 | 0.74 | TACR2 (0.44) | TACR2TACR1HRH1PTGDR2ALDH1A1 | |
| SCHEMBL9260920 | 0.74 | KDM4E (0.50) | PTGDR2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9253881 | 0.74 | HRH1 (0.58) | TACR2TACR1HRH1KDM4E | |
| SCHEMBL9259114 | 0.73 | HRH1 (0.73) | TACR2TACR1HRH1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380731-A | Antiallergic compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0561973-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010491-A1 | ANTIALLERGIC COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-06-25 | — | — | WO | disclosed |