Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | KHK | P50053 | 5/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.38 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12564065 | 0.76 | ABCB1 (0.43) | ABCB1NSD3HTR6PTGDR2ALDH1A1 | |
| SCHEMBL2851940 | 0.76 | KHK (0.47) | ABCB1KHKNSD3HTR6ALDH1A1 | |
| SCHEMBL24117847 | 0.75 | PTGDR2 (0.40) | ADRA1AHRH1ADRA1BKHKTEAD1 | |
| Hydrochloric Acid SCHEMBL1991841 | 0.75 | ABCB1 (0.43) | ABCB1NSD3HTR6PTGDR2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL15658181 | 0.74 | KHK (0.46) | ABCB1KHKSLC6A4NSD3HTR6 | |
| SCHEMBL9284262 | 0.73 | SLC6A4 (0.49) | SLC6A4HTR6 | |
| SCHEMBL19501177 | 0.72 | ADRA1A (0.45) | ADRA1AHRH1ADRA1BCNR2ALDH1A1 | |
| SCHEMBL27540455 | 0.72 | PDE4A (0.45) | CNR2PTGDR2 | |
| SCHEMBL24289745 | 0.71 | TEAD1 (0.41) | CNR2TEAD1TEAD4TEAD2SLC6A4 | |
| SCHEMBL3049374 | 0.70 | ADRA1A (0.49) | ADRA1AHRH1ADRA1BCNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393761-A | Treatment of nervous system disorders | H. LUNDBECK A/S (DK) | 1995-02-28 | — | — | US | disclosed |
| EP-0470039-B1 | Novel 3-arylindole and 3-arylindazole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-07 | — | — | EP | disclosed |
| EP-0470039-A2 | Novel 3-arylindole and 3-arylindazole derivatives | H. LUNDBECK A/S (DK) | 1992-02-05 | — | — | EP | disclosed |