Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 11/20 | 0.50 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 3/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201962 | 0.75 | — | — | |
| SCHEMBL2744048 | 0.70 | — | — | |
| SCHEMBL6570471 | 0.69 | SCN9A (0.38) | CA12CA9CA1CA2CA14 | |
| SCHEMBL7059355 | 0.69 | SCN9A (0.38) | CA12CA9CA1CA2CA14 | |
| SCHEMBL7281508 | 0.68 | SCN9A (0.39) | — | |
| SCHEMBL9790582 | 0.68 | FDPS (0.53) | FDPSFDFT1CA12CA1MMP8 | |
| SCHEMBL9790836 | 0.67 | FDPS (0.50) | FDPSFDFT1CA12CA9MMP2 | |
| SCHEMBL7487716 | 0.67 | — | — | |
| SCHEMBL17187256 | 0.67 | FDPS (0.46) | FDPSFDFT1CA12CA9MMP2 | |
| SCHEMBL5156538 | 0.67 | FDPS (1.00) | FDPSFDFT1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0274346-B1 | SUBSTITUTED AMINOMETHANE-DIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | claimed |
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | claimed |
| EP-0537008-B1 | Use of biphosphonates for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes | SQUIBB & SONS INC (US) | 1995-10-25 | — | — | EP | disclosed |
| EP-0537008-A1 | Use of biphosphonates for the manufacture of a medicament for blocking neoplastic transformation of cells induced by ras oncogenes | E.R. SQUIBB & SONS, INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0513760-A2 | Use of biphosphonate squalene synthetase inhibitors in pharmaceutical compositions useful in lowering cholesterol | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5057505-A | Treatment of illnesses attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | disclosed |