Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789825 | 0.74 | GABRA1 (0.36) | LMNACAMK1DCYP1A2KMT2A | |
| SCHEMBL21275008 | 0.71 | MAPK1 (0.36) | MAPK1CYP1A2RECQLMCL1PTGS1 | |
| SCHEMBL11273314 | 0.68 | MAPK1 (0.41) | LMNAMAPK1CYP1A2RECQLMCL1 | |
| SCHEMBL21274846 | 0.67 | MAPK1 (0.41) | MAPK1MCL1KMT2A | |
| SCHEMBL9315626 | 0.67 | CYP2D6 (0.36) | LMNAMAPK1CYP1A2RECQLMCL1 | |
| SCHEMBL374935 | 0.66 | MAPK1 (0.47) | MAPK1CYP1A2RECQLMCL1 | |
| SCHEMBL31276435 | 0.66 | MAPK1 (0.47) | MAPK1CYP1A2RECQLMCL1 | |
| SCHEMBL25061 | 0.66 | MAPK1 (0.47) | MAPK1CYP1A2RECQLMCL1 | |
| SCHEMBL15692218 | 0.66 | MAPK1 (0.36) | MAPK1CYP1A2RECQLMCL1KMT2A | |
| SCHEMBL3780480 | 0.65 | MAPK1 (0.41) | MAPK1CYP1A2RECQLMCL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5420343-A | ANTIINFLAMMATORY AGENTS; CYCLOOXYGENASE INHIBITORS | G. D. SEARLE & CO. (US) | 1995-05-30 | — | — | US | disclosed |