Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 5/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9286587 | 1.00 | ALOX5 (0.43) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9127947 | 1.00 | ALOX5 (0.43) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9286597 | 1.00 | ALOX5 (0.43) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9126981 | 0.88 | ALOX5 (0.53) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL2107872 | 0.87 | TRIM24 (0.34) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9230759 | 0.81 | ALOX5 (0.41) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9125544 | 0.81 | ALOX5 (0.57) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9098432 | 0.79 | ALOX5 (0.42) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9098152 | 0.78 | ALOX5 (0.43) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 | |
| SCHEMBL9127043 | 0.74 | ALOX5 (0.57) | ALOX5CYP11B2CYP11B1CYP1A2TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995004055-A1 | THIAZOLE DERIVATIVES AS LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |