Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.50 |
| ▸ | DRD3 | P35462 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 5/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | HRH2 | P25021 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | HRH1 | P35367 | 2/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204835 | 0.90 | HTR1A (0.59) | DRD4DRD2DRD3HTR1ASLC6A2 | |
| SCHEMBL9199848 | 0.82 | HTR1A (0.64) | DRD4DRD2DRD3HTR1ASLC6A2 | |
| SCHEMBL9282957 | 0.81 | DRD4 (0.49) | DRD4DRD2DRD3HTR1ASLC6A2 | |
| SCHEMBL240727 | 0.80 | HTR1A (0.55) | DRD2DRD3HTR1AADRA1ADRD1 | |
| SCHEMBL5366747 | 0.78 | HTR1A (0.60) | DRD2DRD3HTR1AADRB1HTR2A | |
| SCHEMBL4395362 | 0.78 | HTR1A (0.56) | DRD4DRD2DRD3HTR1ASLC6A2 | |
| SCHEMBL9284653 | 0.78 | HTR1A (0.62) | DRD4DRD2DRD3HTR1ASLC6A2 | |
| SCHEMBL9287039 | 0.78 | HTR1A (0.62) | DRD4DRD2DRD3HTR1ASLC6A2 | |
| SCHEMBL1307825 | 0.77 | KCNH2 (0.76) | DRD2HTR1AADRB1SIGMAR1KDM4E | |
| Hydrochloric Acid SCHEMBL9639755 | 0.77 | HTR1A (0.61) | DRD4DRD2DRD3HTR1ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434561-B1 | 1-Naphthyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-10-18 | — | — | EP | disclosed |
| US-5166157-A | Analgesics, antidepressants or psychological disorders | ADIR ET COMPAGNIE (FR) | 1992-11-24 | — | — | US | disclosed |
| US-5166156-A | Headaches, schizophrenia; stress relieving; analgesics, anxiolytics, antidepressants; hypotensive agents | ADIR ET COMPAGNIE (FR) | 1992-11-24 | — | — | US | disclosed |
| US-5162324-A | Naphyl piperazines useful as 5-HT1A receptor ligands | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |
| US-5162321-A | 1-naphthyl piperazines useful as 5-HT1A receptor ligands | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |
| US-5143916-A | Hypotensive agents | ADIR ET COMPAGNIE (FR) | 1992-09-01 | — | — | US | disclosed |
| EP-0434561-A2 | 1-Naphthyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-06-26 | — | — | EP | disclosed |