Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9100128 | 0.86 | POLB (0.44) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9108282 | 0.86 | POLB (0.44) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9100121 | 0.86 | POLB (0.44) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9103602 | 0.85 | POLB (0.46) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9104417 | 0.84 | POLB (0.43) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9102776 | 0.84 | SLC6A4 (0.44) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9277892 | 0.84 | ALDH1A1 (0.43) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9104412 | 0.84 | HRH3 (0.43) | CHRM2HRH3ALDH1A1KDM4EALOX12 | |
| SCHEMBL9101647 | 0.84 | ALDH1A1 (0.43) | POLBCHRM2ADRA2BDRD3SIGMAR1 | |
| SCHEMBL9101652 | 0.84 | ALDH1A1 (0.43) | POLBCHRM2ADRA2BDRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012074469-A1 | NEW IKACH BLOCKERS | ASTRAZENECA AB (SE) | 2012-06-07 | — | — | WO | disclosed |