Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 12/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9288392 | 1.00 | DOT1L (0.38) | DOT1LPRMT5PRMT7ALDH1A1CYP1A2 | |
| SCHEMBL9109730 | 0.88 | DOT1L (0.54) | DOT1LALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL9109724 | 0.88 | DOT1L (0.54) | DOT1LALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL9104087 | 0.85 | DOT1L (0.46) | DOT1LPRMT5ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9104097 | 0.85 | DOT1L (0.46) | DOT1LPRMT5ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL18130000 | 0.84 | CYP1A2 (0.38) | DOT1LPRMT5PRMT7ALDH1A1CYP1A2 | |
| SCHEMBL9288530 | 0.83 | DOT1L (0.42) | DOT1LPRMT5PRMT7ALDH1A1CYP1A2 | |
| SCHEMBL9286361 | 0.82 | CYP1A2 (0.37) | DOT1LPRMT5PRMT7ALDH1A1CYP1A2 | |
| SCHEMBL9289347 | 0.82 | DOT1L (0.57) | DOT1LPRMT5PRMT7 | |
| SCHEMBL9111157 | 0.80 | DOT1L (0.57) | DOT1LPRMT5ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160251390-A1 | 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. | 2016-09-01 | — | — | US | disclosed |
| US-9145438-B2 | 7-deazapurine modulators of histone methyltransferase, and methods of use thereof | Epizyme, Inc. (US) | 2015-09-29 | — | — | US | disclosed |
| EP-2646454-B1 | 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | EPIZYME INC (US) | 2015-07-08 | — | — | EP | disclosed |
| US-8722877-B2 | 7-deazapurine modulators of histone methyltransferase, and methods of use thereof | Epizyme, Inc. (US) | 2014-05-13 | — | — | US | disclosed |
| US-20140073597-A1 | 7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. (US) | 2014-03-13 | — | — | US | disclosed |
| US-20130310334-A1 | 7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof | Epizyme, Inc. (US) | 2013-11-21 | — | — | US | disclosed |
| EP-2646454-A2 | 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-10-09 | — | — | EP | disclosed |
| WO-2012075500-A2 | 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073597-A1 | 7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof | TPMT, HNMT, EHMT1 | DOT1L 5/4885PRMT5 43/4885PRMT7 41/4885 |
| US-20130310334-A1 | 7-Deazapurine Modulators of Histone Methyltransferase, and Methods of Use Thereof | TPMT, HNMT, EHMT1 | DOT1L 5/4885PRMT5 43/4885PRMT7 41/4885 |
| US-20160251390-A1 | 7-DEAZAPURINE MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | TPMT, HNMT, EHMT1 | DOT1L 5/4885PRMT5 43/4885PRMT7 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.