Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300327 | 0.81 | POLB (0.43) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL1290821 | 0.70 | NR4A3 (0.42) | POLBAGTR1GAATDP1L3MBTL1 | |
| SCHEMBL16447824 | 0.70 | PTGER1 (0.41) | POLBKDM4EMAPTALKBH1 | |
| SCHEMBL951965 | 0.68 | MEN1 (0.51) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL20669578 | 0.67 | DYRK1A (0.43) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL20345576 | 0.67 | SLC22A12 (0.39) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL23938202 | 0.66 | CYP1A2 (0.35) | MEN1KMT2ACYP1A2CYP2C19ELANE | |
| SCHEMBL7303942 | 0.66 | PDE4D (0.51) | MEN1KMT2ACYP1A2GAAKDM4E | |
| SCHEMBL18024814 | 0.64 | POLB (0.36) | POLBMEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL1290672 | 0.63 | KDM4E (0.41) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012072512-A1 | N-CYCLOBUTYL-IMIDAZOPYRIDINE OR -PYRAZOLOPYRIDINE CARBOXAMIDES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |