SCHEMBL9290357

SCHEMBL9290357

CN1C(=O)c2cccc3c(-c4cc5cccc6ccc7cccc4c7c65)ccc1c23

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.49
BRD4 O60885 12/20 0.46
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
USP2 O75604 2/20 0.44
KEAP1 Q14145 2/20 0.44
NFE2L2 Q16236 2/20 0.44
ATM Q13315 1/20 0.44
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HPGD P15428 1/20 0.44
POLB P06746 1/20 0.43
PRMT1 Q99873 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290441 0.85 PKM (0.52) PKMBRD4MEN1KMT2AUSP2
SCHEMBL9290409 0.80 BRD4 (0.48) PKMBRD4MEN1KMT2AUSP2
SCHEMBL9290356 0.80 BRD4 (0.50) PKMBRD4MEN1KMT2AUSP2
SCHEMBL1101925 0.76 KMT2A (0.62) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL9290415 0.76 BRD4 (0.58) PKMBRD4MEN1KMT2AUSP2
SCHEMBL9290412 0.75 BRD4 (0.52) PKMBRD4MEN1KMT2AUSP2
SCHEMBL15398140 0.74 BRD4 (0.53) PKMBRD4MEN1KMT2AUSP2
SCHEMBL12869500 0.74 KMT2A (0.73) PKMMEN1KMT2AUSP2KEAP1
Benzene SCHEMBL28738256 0.74 CYP1A2 (0.59) MEN1KMT2AKDM4EALDH1A1HPGD
SCHEMBL9290460 0.73 BRD4 (0.53) PKMBRD4MEN1KMT2AUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 PKM 1698/4885BRD4 3880/4885MEN1 3537/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.