SCHEMBL9290452

SCHEMBL9290452

O=C1c2cccc3c(-c4ccc(Sc5ccccc5)cc4)ccc(c23)N1c1ccc(C(F)(F)F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE6D O43924 1/20 0.46
KDM4E B2RXH2 6/20 0.39
USP2 O75604 4/20 0.39
KMT2A Q03164 4/20 0.39
ALDH1A1 P00352 4/20 0.39
HTT P42858 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KEAP1 Q14145 2/20 0.39
NFE2L2 Q16236 2/20 0.39
MAPT P10636 1/20 0.39
POLB P06746 3/20 0.37
RECQL P46063 2/20 0.37
CASP6 P55212 2/20 0.37
TDP1 Q9NUW8 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
APOBEC3A P31941 1/20 0.37
APOBEC3G Q9HC16 1/20 0.37
GALR3 O60755 1/20 0.37
HTR4 Q13639 1/20 0.37
MEN1 O00255 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290378 0.90 PDE6D (0.52) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290432 0.90 PDE6D (0.49) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290416 0.90 PDE6D (0.48) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290444 0.89 PDE6D (0.50) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290457 0.85 PDE6D (0.46) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290346 0.85 PDE6D (0.46) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL12561357 0.85 ALDH1A1 (0.47) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290348 0.84 PDE6D (0.46) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290450 0.83 KMT2A (0.47) PDE6DKDM4EUSP2KMT2AALDH1A1
SCHEMBL9290435 0.82 KMT2A (0.48) PDE6DKMT2AMEN1NR1H3TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 PDE6D 69/4885KDM4E 4060/4885USP2 3865/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.