SCHEMBL9290455

SCHEMBL9290455

C=Cc1cccc(N2C(=O)c3cccc4c(-c5ccc(C(F)(F)F)cc5)ccc2c34)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H3 Q13133 1/20 0.37
KMT2A Q03164 6/20 0.36
MEN1 O00255 5/20 0.36
USP2 O75604 5/20 0.36
HTT P42858 4/20 0.36
ALDH1A1 P00352 4/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
TNNI3 P19429 1/20 0.36
TNNT2 P45379 1/20 0.36
TNNC1 P63316 1/20 0.36
TLR9 Q9NR96 1/20 0.36
KEAP1 Q14145 4/20 0.36
NFE2L2 Q16236 4/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
LMNA P02545 1/20 0.36
PDE6D O43924 1/20 0.35
GALR3 O60755 1/20 0.34
HTR4 Q13639 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9290374 0.87 PDE6D (0.44) NR1H3KMT2AMEN1USP2HTT
SCHEMBL12561361 0.86 KMT2A (0.44) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290432 0.85 PDE6D (0.49) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290416 0.85 PDE6D (0.48) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290436 0.84 KMT2A (0.42) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290347 0.83 PDE6D (0.39) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290353 0.83 PDE6D (0.39) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290454 0.81 MEN1 (0.42) NR1H3KMT2AMEN1USP2HTT
SCHEMBL9290378 0.80 PDE6D (0.52) NR1H3KMT2AMEN1USP2HTT
SCHEMBL12561357 0.80 ALDH1A1 (0.47) NR1H3KMT2AMEN1USP2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8350054-B2 Optical filter ADEKA CORPORATION (JP) 2013-01-08 US disclosed
EP-2458941-A1 OPTICAL FILTER Adeka Corporation (JP) 2012-05-30 EP disclosed
US-20110152538-A1 OPTICAL FILTER ADEKA CORPORATION (JP) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152538-A1 OPTICAL FILTER C1R, CBR3, CBR1 NR1H3 152/4885KMT2A 4130/4885MEN1 3537/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.