Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8133790 | 0.91 | KCNH2 (0.57) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8133566 | 0.85 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL29406230 | 0.85 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8134406 | 0.85 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8156650 | 0.85 | KCNH2 (0.68) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL9773824 | 0.84 | KCNH2 (0.79) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8121724 | 0.83 | ALDH1A1 (0.56) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL5570141 | 0.82 | KCNH2 (0.79) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL8136907 | 0.82 | KCNH2 (0.70) | KCNH2KDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL5566754 | 0.82 | KDM4E (0.74) | KCNH2KDM4EALDH1A1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342846-A | 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents | SYNPHAR LABORATORIES, INC. (CA) | 1994-08-30 | — | — | US | disclosed |
| WO-1993024481-A1 | 7-SUBSTITUTED-6-FLUORO-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID COMPOUNDS AND RELATED COMPOUNDS AS ANTIBACTERIAL AGENTS | SYNPHAR LABORATORIES, INC. (CA) | 1993-12-09 | — | — | WO | disclosed |