Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Glutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | TSHR | P16473 | 6/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.62 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.61 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.61 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.59 |
| ▸ | GABRP | O00591 | 1/20 | 0.59 |
| ▸ | GABRD | O14764 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL9805513 | 1.00 | SLC22A6 (0.92) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL27737294 | 0.96 | SLC22A6 (0.85) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL158774 | 0.96 | SLC22A6 (1.00) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL27601182 | 0.96 | SLC22A6 (1.00) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL7414 | 0.96 | — | — | |
| Glutarate SCHEMBL6701735 | 0.96 | — | — | |
| Glutarate SCHEMBL162952 | 0.92 | SLC22A6 (0.92) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL8618878 | 0.92 | SLC22A6 (0.92) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL1527796 | 0.92 | SLC22A6 (0.92) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL11453117 | 0.92 | SLC22A6 (0.92) | SLC22A6LMNATSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1338934-A | Mono-acyloxy aralkyl neuronuscular relaxants | NEWLAXANT L L C (US) | 2002-03-06 | — | — | CN | claimed |
| CN-1280578-A | Bis-quaternary ammonium derivatives as neuromuscular relaxants | NEWLAKSONT CO LTD (US) | 2001-01-17 | — | — | CN | claimed |
| EP-1025099-A1 | BIS-QUATERNARY AMMONIUM DERIVATIVES AS NEUROMUSCULAR RELAXANTS | Gyermek, Laszlo (US) | 2000-08-09 | — | — | EP | claimed |
| WO-1999021854-A1 | BIS-QUATERNARY AMMONIUM DERIVATIVES AS NEUROMUSCULAR RELAXANTS | NEWLAXANT LLC (US) | 1999-05-06 | — | — | WO | claimed |
| EP-2927250-B1 | (FUMARIC ACID DIESTER)-(CINNAMIC ACID ESTER) COPOLYMER, METHOD FOR PRODUCING SAME, AND FILM PRODUCED USING SAME | TOSOH CORP (JP) | 2017-08-16 | — | — | EP | disclosed |
| US-9512284-B2 | Fumaric acid diester-cinnamic acid ester-based copolymer, production method thereof and film using the same | TOSOH CORPORATION (JP) | 2016-12-06 | — | — | US | disclosed |
| US-9321017-B2 | Gas-separation membrane | NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE (JP) | 2016-04-26 | — | — | US | disclosed |
| US-20150291751-A1 | FUMARIC ACID DIESTER-CINNAMIC ACID ESTER-BASED COPOLYMER, PRODUCTION METHOD THEREOF AND FILM USING THE SAME | TOSOH CORPORATION (JP) | 2015-10-15 | — | — | US | disclosed |
| EP-2927250-A1 | (FUMARIC ACID DIESTER)-(CINNAMIC ACID ESTER) COPOLYMER, METHOD FOR PRODUCING SAME, AND FILM PRODUCED USING SAME | Tosoh Corporation (JP) | 2015-10-07 | — | — | EP | disclosed |
| US-20150033945-A1 | GAS-SEPARATION MEMBRANE | NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE (JP) | 2015-02-05 | — | — | US | disclosed |
| US-8222446-B2 | Method for producing dihydroxybenzene derivative | MITSUI CHEMICALS, INC. (JP) | 2012-07-17 | — | — | US | disclosed |
| US-20110004013-A1 | METHOD FOR PRODUCING DIHYDROXYBENZENE DERIVATIVE | MITSUI CHEMICALS, INC. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2269976-A1 | PROCESS FOR PRODUCING DIHYDROXYBENZENE DERIVATIVE | Mitsui Chemicals, Inc. (JP) | 2011-01-05 | — | — | EP | disclosed |
| US-7101630-B2 | Diarylamino group-containing copolymer, organic electroluminescent device, and method of producing hole transport layer for organic electroluminescent device | KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) | 2006-09-05 | — | — | US | disclosed |
| US-20050008893-A1 | Diarylamino group-containing copolymer, organic electroluminescent device, and method of producing hole transport layer for organic electroluminescent device | KAWAMURA INSTITUTE OF CHEMICAL RESEARCH (JP) | 2005-01-13 | — | — | US | disclosed |
| US-6376510-B1 | ADMINISTERING A ALKOXY- AND ACYLOXY-SUBSTITUTED ARALKYL AND ARALKENYL BIS QUATERNARY AMMONIUM DERIVATIVES OF CYCLIC ALKANOL DIESTERS TO A HUMAN AS MUSCLE RELAXANTS | NEWLAXANT LLC | 2002-04-23 | — | — | US | disclosed |
| CN-1338934-A | Mono-acyloxy aralkyl neuronuscular relaxants | NEWLAXANT L L C (US) | 2002-03-06 | — | — | CN | disclosed |
| US-4252529-A | AMINOPHENOL OR AMINONAPHTHOL COMPOUND WITH SUBSTITUTED FIBER-REACTIVE RADICAL | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110004013-A1 | METHOD FOR PRODUCING DIHYDROXYBENZENE DERIVATIVE | UBE2B, UBE2G2, TUBB2B | SLC22A6 2998/4885LMNA 3340/4885TSHR 2733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.